Conference Agenda
Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).
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Session Overview |
| Date: Tuesday, 01/July/2025 | ||
| 9:00am - 10:00am |
Plenary 2: Plenary Lecture 2: Xinxin Ding, Drug and steroid metabolism using animal model systems. Location: Auditorium 003 Chair: Prof. Vlada B. Urlacher, Heinrich Heine University Düsseldorf, Germany |
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| 10:00am - 11:30am |
P450 Bioinformatics: Symposia 3: P450 Bioinformatics Location: Auditorium 003 Chair: Dr. David Ralph Nelson, University of Tennessee Health Science Center, United States of America Biomolecular simulations of Cytochrome P450 enzymes 10:30am - 11:00am Insights into the structural diversity of the cytochrome P450s 11:00am - 11:15am Integrating structural data to enhance CYP annotation in the P450Atlas 11:15am - 11:30am Defining the worldwide diversity of cytochrome P450s |
P450 Biophysics: Symposia 4: P450 Biophysics Location: Auditorium 004 Chair: Prof. Gianfranco Gilardi, University of Torino, United Kingdom Direct Isolation and Reconstitution of Cytochrome Proteins in Polymer-Based Nanodiscs 10:30am - 11:00am Hydroxylation and lyase reaction mechanisms in CYP17A1 11:00am - 11:30am Biased P450 activation by controlling P450 oxidoreductase conformational sampling: A single molecule and machine learning perspective |
| 11:30am - 12:00pm |
Morning Tea: Morning Tea |
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| 12:00pm - 1:00pm |
P450 Bioinformatics 2: Session 3 continued: P450 Bioinformatics Location: Auditorium 003 Chair: Dr. David Ralph Nelson, University of Tennessee Health Science Center, United States of America Exploring novel P450 enzymes & redox partners from extremophilic regions by a metagenomic approach 12:15pm - 12:30pm Two cytochrome P450 enzymes found in the resin acid-degrading bacterium Pseudomonas abieticivorans 12:30pm - 1:00pm Tracing evolutionary pathways of P450s using ancestral sequence reconstruction |
P450 Biophysics 2: Symposia 4: P450 Biophysics continued Location: Auditorium 004 Chair: Prof. Gianfranco Gilardi, University of Torino, United Kingdom Focusing the computational microscope on the dynamics of mammalian cytochrome P450s and their redox partners 12:30pm - 12:45pm Elucidating Biochemistry of Cytochrome P450 2U1 with respect to Lipid and Xenobiotic Metabolism 12:45pm - 1:00pm Docking predictivity determinants for the P450 flexible active site |
| 1:00pm - 2:00pm |
Lunch 1 July: Lunch 1 July Location: Poster Gallery |
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| 2:00pm - 4:00pm |
P450 Catalytic Mechanisms: Symposia 6 Catalytic Mechanisms of Cytochrome P450 Location: Auditorium 004 Chair: Prof. John C Hackett, Florida International University, United States of America Applications of small angle scattering to delineate P450-membrane and redox partner interactions. 2:30pm - 3:00pm Mechanistic insights from new(ish) radical clock mechanistic probes 3:00pm - 3:30pm Cofactor-free hydroxylation of aliphatic C–H bonds by bacterial cytochrome P450 and peroxygenase enzymes 3:30pm - 4:00pm Emerging roles of extrahepatic cytochrome p450s in lipid and drug metabolism |
P450 protein interactions: Symposia 5 Protein Interactions Location: Auditorium 003 Chair: Dr. Wayne L. Backes, LSU Health Sciences Center, United States of America Chair: Dr. Dmitri R. Davydov, Washington State University, United States of America Functional effects of protein-protein interactions in cytochrome P450 ensemble and their manifestation in the impact of alcohol on drug metabolism 2:25pm - 2:55pm Cytochrome P450 CYP2D6 and heme oxygenase-1 exist as a complex that affects both CYP2D6 and HO-1 function 2:55pm - 3:25pm Tandem reactions of P450s and FMOs in xenobiotic metabolism 3:25pm - 3:55pm Functional interactomics of cytochrome P450s |
| 4:00pm - 6:00pm |
Poster Session 1: Poster Session 1 and Afternoon Tea Location: Poster Gallery |
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